[HTML][HTML] Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome
M Gierhardt, O Pak, D Walmrath… - European …, 2021 - Eur Respiratory Soc
Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or
local pulmonary inflammation, such as caused by severe acute respiratory syndrome …
local pulmonary inflammation, such as caused by severe acute respiratory syndrome …
The leukotriene receptor antagonist montelukast as a potential COVID-19 therapeutic
L Aigner, F Pietrantonio… - Frontiers in molecular …, 2020 - frontiersin.org
The emergence and global impact of COVID-19 has focused the scientific and medical
community on the pivotal influential role of respiratory viruses as causes of severe …
community on the pivotal influential role of respiratory viruses as causes of severe …
A novel strategy to mitigate the hyperinflammatory response to COVID-19 by targeting leukotrienes
CD Funk, A Ardakani - Frontiers in pharmacology, 2020 - frontiersin.org
SARS-CoV-2 causing coronavirus disease 2019 (COVID-19) has wreaked havoc during the
global pandemic of 2020 infecting millions and leaving over a half million dead. As a new …
global pandemic of 2020 infecting millions and leaving over a half million dead. As a new …
Saroglitazar, a dual PPAR-α/γ agonist, alleviates LPS-induced hepatic and renal injury in rats
MR Francis, AR El-Sheakh, GM Suddek - International …, 2023 - Elsevier
Background Lipopolysaccharide (LPS), an endotoxin within gram-negative bacteria, is
associated with systemic acute inflammatory response after invading living tissues and …
associated with systemic acute inflammatory response after invading living tissues and …
Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-κB, NLRP3 inflammasome, and autophagy pathways
Diabetic nephropathy (DN) is reported as one of the most serious microvascular diabetic
complications and the trigger of end-stage renal disease (ESRD), underscoring the concern …
complications and the trigger of end-stage renal disease (ESRD), underscoring the concern …
The therapeutic role of lactobacillus and montelukast in combination with metformin in diabetes mellitus complications through modulation of gut microbiota and …
Male reproductive dysfunction is one of the overlooked findings of diabetes mellitus (DM)
that deserves greater scientific attention. This study is designed to explore the therapeutic …
that deserves greater scientific attention. This study is designed to explore the therapeutic …
A novel role of nifuroxazide in attenuation of sepsis-associated acute lung and myocardial injuries; role of TLR4/NLPR3/IL-1β signaling interruption
Acute lung injury (ALI) and the subsequent multi-system organ failure is a serious health
problem with devastating impacts on the health care systems. Indeed, the world has been …
problem with devastating impacts on the health care systems. Indeed, the world has been …
Kidney in the net of acute and long-haul coronavirus disease 2019: a potential role for lipid mediators in causing renal injury and fibrosis
KC Chiang, JD Imig, K Kalantar-Zadeh… - Current opinion in …, 2022 - journals.lww.com
Summary In COVID-19, the lipid-mediator storm promotes thromboinflammation, ischemia–
reperfusion injury and cytotoxicity. The thromboxane A 2 and PGD 2 signaling presents a …
reperfusion injury and cytotoxicity. The thromboxane A 2 and PGD 2 signaling presents a …
Montelukast induces beneficial behavioral outcomes and reduces inflammation in male and female rats
IS Rostevanov, B Betesh-Abay, A Nassar… - Frontiers in …, 2022 - frontiersin.org
Background Accumulative data links inflammation and immune dysregulation to the
pathophysiology of mental disorders; little is known regarding leukotrienes'(LTs) …
pathophysiology of mental disorders; little is known regarding leukotrienes'(LTs) …
Montelukast ameliorates Concanavalin A-induced autoimmune hepatitis in mice via inhibiting TNF-α/JNK signaling pathway
DH El-Kashef, RS Abdelrahman - Toxicology and Applied Pharmacology, 2020 - Elsevier
Abstract Background Concanavalin A (ConA) is a well-established model to induce
autoimmune hepatitis (AIH) in mice which mimics pathological alterations that occur in …
autoimmune hepatitis (AIH) in mice which mimics pathological alterations that occur in …