Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Melanoma is the deadliest form of skin cancer and its incidence is rising, creating a costly
and significant clinical problem. Exposure to ultraviolet (UV) radiation, namely UVA (315 …

Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but
there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC …

Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and …

The use of intravenous vitamin C (IVC) for cancer therapy has long been an area of intense
controversy. Despite this, high dose IVC has been administered for decades by …

Vitamin C (VitC), in addition to its role as a general antioxidant, has long been considered to
possess direct anti-cancer activity at high doses. VitC acts through oxidant and epigenetic …

Colorectal cancer (CRC) is continuously classified as one of the most incidental and mortal
types of cancer worldwide. The positive outcomes of the conventional chemotherapy are …

A new series of hybrid compounds with tropinone and thiazole rings in the structure was
designed and synthesized as potential anticancer agents. They were tested against human …

Purpose Traditional treatment regimens for advanced prostate cancer, especially castration-
resistant prostate cancer, result in low survival times with severe side effects. Therefore, new …

A hypoxic tumor microenvironment is linked to poor prognosis. It promotes tumor cell
dedifferentiation and metastasis and desensitizes tumor cells to type-I IFN, chemotherapy …