The role of interoception and its neural basis with relevance to drug addiction is reviewed.
Interoception consists of the receiving, processing, and integrating body-relevant signals …

Learned associations between drugs and environment play an important role in addiction
and are thought to be encoded within specific patterns of sparsely distributed neurons called …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Much remains unknown about the etiology of compulsion-like alcohol drinking, where
consumption persists despite adverse consequences. The role of the anterior insula (AIC) in …

Healthy brain function requires a balance between the activity of dopamine receptor 1 (D1)
and dopamine receptor 2 (D2). Alterations in this balance increase the risk for numerous …

Abstract Rationale and Objectives The prefrontal cortex is critical for execution and inhibition
of reward seeking. Neural manipulation of rodent medial prefrontal cortex (mPFC) …

A number of neuroimaging studies have shown that drug addiction is associated with
morphological differences in several brain areas, including orbito-frontal and limbic …

Alcohol use disorder extracts substantial personal, social and clinical costs, and continued
intake despite negative consequences (compulsion-like consumption) can contribute …

Cocaine addiction is a harmful preference for drug use over and at the expense of other
nondrug-related activities. Here we identify in the rat orbitofrontal cortex (OFC) a mechanism …

Alcohol abuse disorders are associated with dysfunction of frontal cortical areas including
the orbitofrontal cortex (OFC). The OFC is extensively innervated by monoamines, and drugs …