Immunopathology of RSV: an updated review

HC Bergeron, RA Tripp - Viruses, 2021 - mdpi.com
RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has
limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding …

Role of type I interferon (IFN) in the respiratory syncytial virus (RSV) immune response and disease severity

DR Hijano, LD Vu, LM Kauvar, RA Tripp… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract
disease in children< 2 years of age. Increased morbidity and mortality have been reported in …

Rapid and quantitative detection of respiratory viruses using surface-enhanced Raman spectroscopy and machine learning

Y Yang, B Xu, J Murray, J Haverstick, X Chen… - Biosensors and …, 2022 - Elsevier
Rapid and sensitive pathogen detection is important for prevention and control of disease.
Here, we report a label-free diagnostic platform that combines surface-enhanced Raman …

Biology of infection and disease pathogenesis to guide RSV vaccine development

S Boyoglu-Barnum, T Chirkova… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract disease
in young children and a substantial contributor to respiratory tract disease throughout life …

Towards a unified classification for human respiratory syncytial virus genotypes

K Ramaekers, A Rector, L Cuypers, P Lemey… - Virus …, 2020 - academic.oup.com
Since the first human respiratory syncytial virus (HRSV) genotype classification in 1998,
inconsistent conclusions have been drawn regarding the criteria that define HRSV …

Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus

M Xue, BS Zhao, Z Zhang, M Lu, O Harder… - Nature …, 2019 - nature.com
Abstract N 6-methyladenosine (m6A) is the most prevalent internal modification of mRNAs in
most eukaryotes. Here we show that RNAs of human respiratory syncytial virus (RSV) are …

Functional features of the respiratory syncytial virus G protein

LJ Anderson, SJ Jadhao, CR Paden, S Tong - Viruses, 2021 - mdpi.com
Respiratory syncytial virus (RSV) is a major cause of serious lower respiratory tract
infections in children< 5 years of age worldwide and repeated infections throughout life …

Structures of respiratory syncytial virus G antigen bound to broadly neutralizing antibodies

SO Fedechkin, NL George, JT Wolff, LM Kauvar… - Science …, 2018 - science.org
Respiratory syncytial virus (RSV) is a top cause of severe lower respiratory tract disease and
mortality in young children and the elderly. The viral envelope G glycoprotein contributes to …

Immunological goals for respiratory syncytial virus vaccine development

BS Graham - Current opinion in immunology, 2019 - Elsevier
Highlights•Immunological goals for vaccination depend on whether it is for primary induction
or boosting of pre-existing immunity.•Boosting neutralizing activity is the major goal for …

Respiratory syncytial virus (RSV) G protein vaccines with central conserved domain mutations induce CX3C-CX3CR1 blocking antibodies

HC Bergeron, J Murray, AM Nuñez Castrejon… - Viruses, 2021 - mdpi.com
Respiratory syncytial virus (RSV) infection can cause bronchiolitis, pneumonia, morbidity,
and some mortality, primarily in infants and the elderly, for which no vaccine is available …