Although the administration of fluid is the first treatment considered in almost all cases of
circulatory failure, this therapeutic option poses two essential problems: the increase in …

In patients with acute circulatory failure, the decision to give fluids or not should not be taken
lightly. The risk of overzealous fluid administration has been clearly established. Moreover …

Background: Sepsis is associated with generalised endothelial injury and capillary leak and
has traditionally been treated with large volume fluid resuscitation. Some patients with …

Purpose We performed a systematic review and meta-analysis of studies investigating the
passive leg raising (PLR)-induced changes in cardiac output (CO) and in arterial pulse …

Purpose Mechanisms of circulatory failure are complex and frequently intricate in septic
shock. Better characterization could help to optimize hemodynamic support. Methods Two …

Introduction This is a state-of-the-art article of the diagnostic process, etiologies and
management of acute right ventricular (RV) failure in critically ill patients. It is based on a …

From the Division of Pulmonary and Critical Care Medicine, Eastern Virginia Medical
School, Norfolk, VA. Address reprint requests to Paul E. Marik, MD, FCCM, FCCP, Eastern …

Modalities of fluid management in patients sustaining the acute respiratory distress
syndrome (ARDS) are challenging and controversial. Optimal fluid management should …

Fluid administration leads to a significant increase in cardiac output in only half of ICU
patients. This has led to the concept of assessing fluid responsiveness before infusing fluid …

Myocardial dysfunction is one of the main predictors of poor outcome in septic patients, with
mortality rates next to 70%. During the sepsis-induced myocardial dysfunction, both …