Metabolic reprogramming by the PI3K-Akt-mTOR pathway in cancer
In the past decade, there has been a resurgence of interest in elucidating how metabolism is
altered in cancer cells and how such dependencies can be targeted for therapeutic gain. At …
altered in cancer cells and how such dependencies can be targeted for therapeutic gain. At …
[HTML][HTML] Polyphenols and their effects on diabetes management: A review
N Aryaeian, SK Sedehi, T Arablou - … of the Islamic Republic of Iran, 2017 - ncbi.nlm.nih.gov
Background: Type 2 diabetes is a growing public health problem and is associated with
increased morbidity and mortality. The worldwide prevalence of type 2 diabetes is rising …
increased morbidity and mortality. The worldwide prevalence of type 2 diabetes is rising …
Mammalian phosphoinositide kinases and phosphatases
T Sasaki, S Takasuga, J Sasaki, S Kofuji… - Progress in lipid …, 2009 - Elsevier
Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling
X Cai, Y Xu, AK Cheung, RC Tomlinson… - Chemistry & biology, 2013 - cell.com
Toll-like receptor (TLR) signaling is a key component of innate immunity. Aberrant TLR
activation leads to immune disorders via dysregulation of cytokine production, such as IL …
activation leads to immune disorders via dysregulation of cytokine production, such as IL …
Phytochemicals and their impact on adipose tissue inflammation and diabetes
A Leiherer, A Mündlein, H Drexel - Vascular pharmacology, 2013 - Elsevier
Type 2 diabetes mellitus is an inflammatory disease and the mechanisms that underlie this
disease, although still incompletely understood, take place in the adipose tissue of obese …
disease, although still incompletely understood, take place in the adipose tissue of obese …
Turning signals on and off: GLUT4 traffic in the insulin-signaling highway
Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by
accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the …
accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the …
Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells
T Kim, J Davis, AJ Zhang, X He, ST Mathews - Biochemical and biophysical …, 2009 - Elsevier
Curcumin, the bioactive component of curry spice turmeric, and its related structures
possess potent anti-oxidant and anti-inflammatory properties. Several lines of evidence …
possess potent anti-oxidant and anti-inflammatory properties. Several lines of evidence …
Regulation of macronutrients in insulin resistance and glucose homeostasis during type 2 diabetes mellitus
Insulin resistance is an important feature of metabolic syndrome and a precursor of type 2
diabetes mellitus (T2DM). Overnutrition-induced obesity is a major risk factor for the …
diabetes mellitus (T2DM). Overnutrition-induced obesity is a major risk factor for the …
Phosphatidylinositol 3, 5-bisphosphate: metabolism and cellular functions
Polyphosphoinositides (PPIn) are low-abundance membrane phospholipids that each bind
to a distinctive set of effector proteins and, thereby, regulate a characteristic suite of cellular …
to a distinctive set of effector proteins and, thereby, regulate a characteristic suite of cellular …
Phosphatidylinositol 3, 5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function
SK Dove, K Dong, T Kobayashi, FK Williams… - Biochemical …, 2009 - portlandpress.com
PtdIns (3, 5) P 2 is one of the seven regulatory PPIn (polyphosphoinositides) that are
ubiquitous in eukaryotes. It controls membrane trafficking at multiple points in the …
ubiquitous in eukaryotes. It controls membrane trafficking at multiple points in the …