Cheminformatics-based discovery of new organoselenium compounds with potential for the treatment of cutaneous and visceral leishmaniasis
Leishmaniasis affects more than 12 million humans globally and a further 1 billion people
are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis coupled …
are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis coupled …
Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation
S Zhu, S Zhong, K Cheng, LS Zhang, J Bai… - Cellular & Molecular …, 2023 - nature.com
Abstract Interleukin-33 (IL-33) is a crucial nuclear cytokine that induces the type 2 immune
response and maintains immune homeostasis. The fine-tuned regulation of IL-33 in tissue …
response and maintains immune homeostasis. The fine-tuned regulation of IL-33 in tissue …
Molecular scaffold recognition of drug molecules against essential genes of leishmania donovani using biocomputing approach
Leishmania donovani, an obligatory intracellular flagellate pathogen, is the underlying
cause of visceral leishmaniasis (VL), a fatal disease that poses a significant challenge to …
cause of visceral leishmaniasis (VL), a fatal disease that poses a significant challenge to …
Engineering pyridoxal kinase PdxY-integrated Escherichia coli strain and optimization for high-level 5-aminolevulinic acid production
C Xue, TH Yu, IS Ng - Journal of the Taiwan Institute of Chemical Engineers, 2021 - Elsevier
Abstract Recently, 5-aminolevulinic acid (ALA) has gained significant attention in research
due to its extensive applications in agriculture, aquaculture, cosmetics, and photodynamic …
due to its extensive applications in agriculture, aquaculture, cosmetics, and photodynamic …
Theoretical activity prediction, structure-based design, molecular docking and pharmacokinetic studies of some maleimides against Leishmania donovani for the …
Background Leishmaniasis is a neglected tropical disease caused by a group of protozoan
of the genus Leishmani a and transmitted to humans majorly through the bite of the female …
of the genus Leishmani a and transmitted to humans majorly through the bite of the female …
A combined 2-D and 3-D QSAR modeling, molecular docking study, design, and pharmacokinetic profiling of some arylimidamide-azole hybrids as superior L …
Background Leishmaniasis is one of the neglected tropical diseases which is prevalent in
the tropical regions of the world most especially in Africa. It is caused by the Leishmania …
the tropical regions of the world most especially in Africa. It is caused by the Leishmania …
Genome-wide association study and transcriptome analysis provide the SNPs and molecular insights into the visceral nodular disease tolerance in half-smooth …
M Chang, K Shi, J Xia, R Zhang, Y Li, S Zang, S Tan… - Aquaculture, 2025 - Elsevier
Half-smooth tongue sole (Cynoglossus semilaevis) is an economic flatfish in seawater
factory farming along the coastal areas of China. However, the farming of C. semilaevis is …
factory farming along the coastal areas of China. However, the farming of C. semilaevis is …
Efficient biotransformation of l-lysine into cadaverine by strengthening pyridoxal 5'-phosphate-dependent proteins in Escherichia coli with cold shock treatment
C Xue, KM Hsu, WW Ting, SF Huang, HY Lin… - Biochemical …, 2020 - Elsevier
Cadaverine is a five-carbon diamine which serves as an important biochemical for the
synthesis of bio-based nylon. It can be produced by the bioconversion of l-lysine with lysine …
synthesis of bio-based nylon. It can be produced by the bioconversion of l-lysine with lysine …
Computational evaluation of the inhibitory potential of some urea, thiourea, and selenourea derivatives of diselenides against leishmaniasis: 2D-QSAR …
Leishmaniasis affects more than twelve million people globally and a further one billion
people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis …
people are at risk in leishmaniasis endemic areas. The lack of a vaccine for leishmaniasis …
Mechanistic and structural insights into vitamin B2 metabolizing enzyme riboflavin kinase from Leishmania donovani
Leishmania donovani relies on specific vitamins and cofactors crucial for its survival and
pathogenesis. Tailoring therapies to disrupt these pathways offers a promising strategy for …
pathogenesis. Tailoring therapies to disrupt these pathways offers a promising strategy for …