Environmental endocrine disruptors and pregnane X receptor action: A review
Y Liang, Y Gong, Q Jiang, Y Yu, J Zhang - Food and Chemical Toxicology, 2023 - Elsevier
The pregnane X receptor (PXR) is a kind of orphan nuclear receptor activated by a series of
ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present …
ligands. Environmental endocrine disruptors (EEDs) are a wide class of molecules present …
Allosteric antagonism of the pregnane X receptor (PXR): current-state-of-the-art and prediction of novel allosteric sites
R Kamaraj, M Drastik, J Maixnerova, P Pavek - Cells, 2022 - mdpi.com
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with
high levels of expression in the liver. It not only plays a key role in drug metabolism and …
high levels of expression in the liver. It not only plays a key role in drug metabolism and …
Non-Kinase Off-Target Inhibitory Activities of Clinically-Relevant Kinase Inhibitors
NR Brauer, AL Kempen, D Hernandez… - European Journal of …, 2024 - Elsevier
Protein kinases are responsible for a myriad of cellular functions, such as cell cycle,
apoptosis, and proliferation. Because of this, kinases make excellent targets for therapeutics …
apoptosis, and proliferation. Because of this, kinases make excellent targets for therapeutics …
Pregnane X receptor as a therapeutic target for cholestatic liver injury
H Lan, Y Zhang, M Fan, B Wu… - Drug Metabolism Reviews, 2023 - Taylor & Francis
Cholestatic liver injury (CLI) is caused by toxic bile acids (BAs) accumulation in the liver and
can lead to inflammation and liver fibrosis. The mechanisms underlying CLI development …
can lead to inflammation and liver fibrosis. The mechanisms underlying CLI development …
[PDF][PDF] Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites. Cells 2022, 11, 2974
R Kamaraj, M Drastik, J Maixnerova, P Pavek - 2022 - academia.edu
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with
high levels of expression in the liver. It not only plays a key role in drug metabolism and …
high levels of expression in the liver. It not only plays a key role in drug metabolism and …