Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid formed during the
metabolism of the essential amino acid methionine. Hcy is considered a risk factor for …

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Background & Aims Several recent clinical studies have shown that serum homocysteine
(Hcy) levels are positively correlated, while vitamin B 12 (B 12) and folate levels are …

Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from
methionine to cysteine. When the fasting plasma Hcy level is higher than 15 μmol/L, it is …

Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …

Epigenetics is a rapidly growing field that studies gene expression modifications not
involving changes in the DNA sequence. Histone H3, one of the basic proteins in the …

Hyperhomocysteinemia (HHcy) exerts a wide range of biological effects and is associated
with a number of diseases, including cardiovascular disease, dementia, neural tube defects …

Quantitative information about the levels and dynamics of post-translational modifications
(PTMs) is critical for an understanding of cellular functions. Protein arginine methylation …

Increased levels of homocysteine have been established as a risk factor for cardiovascular
disease (CVD) by mechanisms still incompletely defined. S-Adenosylhomocysteine (SAH) is …

S-adenosylhomocysteine (SAH) can induce endothelial dysfunction and activation,
contributing to atherogenesis; however, its role in the activation of the inflammatory mediator …