Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen
activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system …

Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin)
superfamily with antiprotease activity, is the main physiological inhibitor of tissue-type (tPA) …

Environmental exposures during early life play a critical role in life-course health, yet the
molecular phenotypes underlying environmental effects on health are poorly understood. In …

Proteolytic activity is fundamental to survival, so it is not surprising that all living organisms
have proteases, especially seine protease. This enzyme in its numerous isoforms and …

Brain-derived neurotrophic factor (BDNF) plays pivotal roles in neuronal function. The
cleaved–mature–form of BDNF (mBDNF), predominantly expressed in adult brains, critically …

It is well-established that complexes of plasminogen-activator inhibitor 1 (PAI-1) with its
target enzymes bind tightly to low-density lipoprotein (LDL) receptor-related protein 1 …

Vitronectin is present in large concentrations in serum and the extracellular matrix. Although
vitronectin is known to modulate neutrophil adhesion and chemotaxis, and to contribute to …

Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-
type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of …

The serpin plasminogen activator inhibitor-1 (PAI-1) is a crucial regulator in fibrinolysis and
tissue remodeling. PAI-1 has been associated with several pathological conditions and is a …

Effective removal of apoptotic cells, particularly apoptotic neutrophils, is essential for the
successful resolution of acute inflammatory conditions. In these experiments, we found that …