Evidence for innate immune memory (or 'priming') in invertebrates has been accumulating
over the last years. We here provide an in-depth review of the current state of evidence for …

There is growing interest in using Drosophila melanogaster to elucidate mechanisms that
underlie the complex relationships between a host and its microbiota. In addition to the …

The genetically tractable model organism Caenorhabditis elegans was first used to model
bacterial virulence in vivo a decade ago. Since then, great strides have been made in …

A characteristic of many neurodegenerative diseases, including Alzheimer's disease (AD),
Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis …

Multiple studies have identified conserved genetic pathways and small molecules
associated with extension of lifespan in diverse organisms. However, extending lifespan …

Memory was traditionally considered an exclusive hallmark of adaptive immunity. This
dogma was challenged by recent reports that myeloid cells can retain 'memory'of earlier …

The nematode Caenorhabditis elegans has been a powerful experimental organism for
almost half a century. Over the past 10 years, researchers have begun to exploit the power …

Invertebrates are the protagonists of a recent paradigm shift because they now show that
vertebrates are not the only group with immune memory. This review discusses the concept …

Intestinal epithelial cells provide an essential line of defense for Caernohabditis elegans
against ingested pathogens. Because nematodes consume microorganisms as their food …

Immune memory has traditionally been the domain of the adaptive immune system, present
only in antigen‐specific T and B cells. The purpose of this review is to summarize the …