An atlas of substrate specificities for the human serine/threonine kinome

JL Johnson, TM Yaron, EM Huntsman, A Kerelsky… - Nature, 2023 - nature.com
Protein phosphorylation is one of the most widespread post-translational modifications in
biology,. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

Tuft and cancer stem cell marker DCLK1: A new target to enhance anti-tumor immunity in the tumor microenvironment

Z Cao, N Weygant, P Chandrakesan, CW Houchen… - Cancers, 2020 - mdpi.com
Simple Summary Doublecortin-like kinase 1 (DCLK1) is a tumor stem cell marker in colon,
pancreatic, and potentially other cancers that has received wide attention recently. Aside …

DCLK1 and its oncogenic functions: a promising therapeutic target for cancers

L Ye, B Liu, J Huang, X Zhao, Y Wang, Y Xu, S Wang - Life Sciences, 2024 - Elsevier
Abstract Doublecortin-like kinase 1 (DCLK1), a significant constituent of the protein kinase
superfamily and the doublecortin family, has been recognized as a prooncogenic factor that …

[HTML][HTML] DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis

JH Kim, SY Park, SE Jeon, JH Choi, CJ Lee… - Theranostics, 2022 - ncbi.nlm.nih.gov
Abstract Rationale: Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that
selectively marks cancer stem-like cells (CSCs) and promotes malignant progression in …

Targeting doublecortin-like kinase 1 reveals a novel strategy to circumvent chemoresistance and metastasis in ovarian cancer

S Dogra, SP Elayapillai, D Qu, K Pitts, A Filatenkov… - Cancer Letters, 2023 - Elsevier
Ovarian cancer (OvCa) has a dismal prognosis because of its late-stage diagnosis and the
emergence of chemoresistance. Doublecortin-like kinase 1 (DCLK1) is a serine/threonine …

Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells

FS Yuliani, JY Chen, WH Cheng, HC Wen… - Journal of Biomedical …, 2022 - Springer
Background Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer
stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL …

Design, synthesis and biological evaluation of novel DCLK1 inhibitor containing purine skeleton for the treatment of pancreatic cancer

Y Chen, L Meng, W Wang, L Ye, L Huang… - European Journal of …, 2023 - Elsevier
Pancreatic cancer is a highly lethal form of malignancy that continues to pose a significant
and unresolved health challenge. Doublecortin-like kinase 1 (DCLK1), a serine/threonine …

Inhibition of DCLK1 with DCLK1-IN-1 suppresses renal cell carcinoma invasion and stemness and promotes cytotoxic T-cell-mediated anti-tumor immunity

L Ding, Y Yang, Y Ge, Q Lu, Z Yan, X Chen, J Du… - Cancers, 2021 - mdpi.com
Simple Summary In this study, we found that the novel small molecule kinase inhibitor
DCLK1-IN-1 not only inhibited DCLK1 phosphorylation, stemness, and EMT-related …

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

ALE Carli, S Afshar‐Sterle, A Rai, H Fang… - …, 2021 - Wiley Online Library
Abstract Doublecortin‐like kinase 1 (DCLK1) is a putative cancer stem cell marker, a
promising diagnostic and prognostic maker for malignant tumors and a proposed driver …

Blocking of doublecortin-like kinase 1-regulated SARS-CoV-2 replication cycle restores cell signaling network

RB Undi, N Ahsan, JL Larabee… - Journal of …, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to fatal
outcomes for subgroups of patients with pre-existing co-morbidities. We previously reported …