Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders with a high
prevalence and impact on society. ASDs are characterized by deficits in both social behavior …

Fragile X syndrome (FXS) is a common form of inherited intellectual disability and is one of
the leading known causes of autism. The mutation responsible for FXS is a large expansion …

Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and is
also linked to other neurologic and psychiatric disorders. FXS is caused by a triplet …

De novo protein synthesis is necessary for long-lasting modifications in synaptic strength
and dendritic spine dynamics that underlie cognition. Fragile X syndrome (FXS) …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

Research on animal models of fragile X syndrome suggests that STX209, a γ-aminobutyric
acid type B (GABAB) agonist, might improve neurobehavioral function in affected patients …

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the
leading monogenic cause of autism. The condition stems from loss of fragile X mental …

Fragile X is the most common known inherited cause of intellectual disability and autism,
and it typically results from transcriptional silencing of FMR1 and loss of the encoded …

Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the
fragile X mental retardation protein, which regulates signal transduction at metabotropic …

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons,
FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these …