Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-
distance cell–cell signalling and thus regulate many developmental processes at the …

Axons are guided along specific pathways by attractive and repulsive cues in the
extracellular environment. Genetic and biochemical studies have led to the identification of …

Eph receptor tyrosine kinases mould the behaviour of many cell types by binding membrane-
anchored ligands, ephrins, at sites of cell–cell contact. Eph signals affect both of the …

The selective elimination of axons, dendrites, axon and dendrite branches, and synapses,
without loss of the parent neurons, occurs during normal development of the nervous system …

Patterns of synaptic connections in the visual system are remarkably precise. These
connections dictate the receptive field properties of individual visual neurons and ultimately …

Cue-directed axon guidance depends partly on local translation in growth cones. Many
mRNA transcripts are known to reside in developing axons, yet little is known about their …

The interactions between Eph receptor tyrosine kinases and their ephrin ligands regulate
cell migration and axon pathfinding. The EphA receptors are generally thought to become …

Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases in
trans on opposing cells. In the developing nervous system, the Eph–ephrin signaling system …

Brain connections are organized into topographic maps that are precisely aligned both
within and across modalities. This alignment facilitates coherent integration of different …

The visual system is beautifully crafted to transmit information of the external world to visual
processing and cognitive centers in the brain. For visual information to be relayed to the …