The advancing validation and exploitation of CSF and blood neurofilament light chain
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …

Neurobiomarkers have attracted significant attention over the last ten years. One promising
biomarker is the neurofilament light chain protein (NfL). Since the introduction of …

The recent development of assays that accurately quantify neurofilament light, a neuronal
cytoskeleton protein, in plasma has generated a vast literature supporting that it is a …

Alzheimer's disease (AD) characterization has progressed from being indexed using clinical
symptomatology followed by neuropathological examination at autopsy to in vivo signatures …

Sepsis is the most common cause of admission to intensive care units worldwide. Sepsis
patients frequently suffer from sepsis-associated encephalopathy (SAE) reflecting acute …

The recent introduction of new-generation immunoassay methods allows the reliable
quantification of structural brain markers in peripheral matrices. Neurofilament light chain …

Neurofilament light chain (NfL) is a long-awaited blood biomarker that can provide clinically
useful information about prognosis and therapeutic efficacy in multiple sclerosis (MS). There …

Neurofilament proteins (Nf) have been validated and established as a reliable body fluid
biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light …

Objectives Neurofilament light chain (NfL) has emerged as a promising biomarker for
detecting and monitoring axonal injury. Until recently, NfL could only be reliably measured in …

INTRODUCTION Blood biomarkers have proven useful in Alzheimer's disease (AD)
research. However, little is known about their biological variation (BV), which improves the …