Macrophages represent the first line of defence in innate immune responses and
additionally serve important functions for the regulation of host inflammation and tissue …

The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic
organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from …

Diabetic kidney disease (DKD) is the main cause of chronic kidney disease (CKD) and
progresses faster in males than in females. We identify sex-based differences in kidney …

Succinate dehydrogenase (SDH) loss-of-function mutations drive succinate accumulation in
tumor microenvironments, for example in the neuroendocrine tumors pheochromocytoma …

Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …

Macrophages are dynamic immune cells that can adopt several activation states.
Fundamental to these functional activation states is the regulation of cellular metabolic …

When microorganisms invade a host, the innate immune system first recognizes the
pathogen-associated molecular patterns of these microorganisms through pattern …

Succinate is an important metabolite that modulates metabolism of immune cells and cancer
cells in the tumor microenvironment (TME). Herein, we report that polyethylene succinate …

The rapidly evolving area of immunometabolism has shed new light on the fundamental
properties of products and intermediates of cellular metabolism (metabolites), highlighting …

Nutrients can impact and regulate cellular metabolism and cell function which is particularly
important for the activation and function of diverse immune subsets. Among the critical …