Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to
bacterial persistence. Staphylococcus aureus, the predominant pathogen in human …

Biomaterial-associated infections (BAIs) are an increasing problem where antibiotic
therapies are often ineffective. The design of novel strategies to prevent or combat infection …

Fracture related infections (FRI) are debilitating and costly complications of musculoskeletal
trauma surgery that can result in permanent functional loss or amputation. Surgical treatment …

Aims Biofilm-related infection is a major complication that occurs in orthopaedic surgery.
Various treatments are available but efficacy to eradicate infections varies significantly. A …

Background Infected bone nonunion is the toughest problem in fracture-related infection,
leading to high disability and recurrence. The aim of this study was to evaluate the …

Fracture healing is impaired in the setting of infection, which begets protracted inflammation.
The most problematic causative agent of musculoskeletal infection is methicillin‐resistant …

Aims To investigate the efficacy of ethylenediaminetetraacetic acid-normal saline (EDTA-
NS) in dispersing biofilms and reducing bacterial infections. Methods EDTA-NS solutions …

Aims Bone regeneration during treatment of staphylococcal bone infection is challenging
due to the ability of Staphylococcus aureus to invade and persist within osteoblasts. Here …

Objectives Case numbers of osteomyelitis are rising and chronic infections remain difficult to
cure. While it is known that the major pathogen Staphylococcus aureus can persist …

Aims In wound irrigation, 1 mM ethylenediaminetetraacetic acid (EDTA) is more efficacious
than normal saline (NS) in removing bacteria from a contaminated wound. However, the …