Strategies based on organ decellularization and recellularization

KH Hillebrandt, H Everwien, N Haep… - Transplant …, 2019 - Wiley Online Library
Transplantation is the only curative treatment option available for patients suffering from end‐
stage organ failure, improving their quality of life and long‐term survival. However, because …

In vivo performance of decellularized vascular grafts: a review article

CH Lin, K Hsia, H Ma, H Lee, JH Lu - International journal of molecular …, 2018 - mdpi.com
Due to poor vessel quality in patients with cardiovascular diseases, there has been an
increased demand for small-diameter tissue-engineered blood vessels that can be used as …

Multifunctional extracellular vesicles and edaravone-loaded scaffolds for kidney tissue regeneration by activating GDNF/RET pathway

SY Lee, JM Park, WK Rhim, EH Lee, SH Lee, JY Kim… - Nano …, 2024 - Springer
With the severity of chronic kidney disease worldwide, strategies to recover renal function
via tissue regeneration provide alternatives to kidney replacement therapy. To exclude side …

Intravital microscopy datasets examining key nephron segments of transplanted decellularized kidneys

PR Corridon - Scientific data, 2022 - nature.com
This study contains intravital microscopy (IVM) data examining the microarchitecture of
acellular kidney scaffolds. Acellular scaffolds are cell-free collagen-based matrices derived …

Decellularization of porcine kidney with submicellar concentrations of SDS results in the retention of ECM proteins required for the adhesion and maintenance of …

T Bongolan, J Whiteley, J Castillo-Prado… - Biomaterials …, 2022 - pubs.rsc.org
When decellularizing kidneys, it is important to maintain the integrity of the acellular
extracellular matrix (ECM), including associated adhesion proteins and growth factors that …

[HTML][HTML] Two Decades of Advances and Limitations in Organ Recellularization

A Stoian, A Adil, F Biniazan, S Haykal - Current issues in molecular …, 2024 - mdpi.com
The recellularization of tissues after decellularization is a relatively new technology in the
field of tissue engineering (TE). Decellularization involves removing cells from a tissue or …

A non-woven path: electrospun poly (lactic acid) scaffolds for kidney tissue engineering

TP Burton, A Callanan - Tissue Engineering and Regenerative Medicine, 2018 - Springer
Chronic kidney disease is a major global health problem affecting millions of people; kidney
tissue engineering provides an opportunity to better understand this disease, and has the …

Kidney bioengineering for transplantation

Y Ibi, R Nishinakamura - Transplantation, 2023 - journals.lww.com
The kidney is an important organ for maintenance of homeostasis in the human body. As
renal failure progresses, renal replacement therapy becomes necessary. However, there is …

[HTML][HTML] Have we hit a wall with whole kidney decellularization and recellularization: A review

MJA de Haan, FMR Witjas, MA Engelse… - Current Opinion in …, 2021 - Elsevier
The purpose of organ decellularization is to remove all cellular components whilst
preserving the extracellular matrix (ECM). It has been hypothesized that this decellularized …

Surface Modification of Decellularized Kidney Scaffold with Chemokine and AKI-CKD Cytokine Juice to Increase the Recellularization Efficiency of Bio-engineered …

M Choi, MA Al Fahad, PC Shanto, S Park, BT Lee - Biomaterials, 2024 - Elsevier
Chronic kidney disease (CKD) is a prevalent global health issue, primarily caused by
glomerular dysfunction, diabetes, endovascular disorders, hypertensive nephrosclerosis …