Metabolomics, which is the metabolites profiling in biological matrices, is a key tool for
biomarker discovery and personalized medicine and has great potential to elucidate the …

Galectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The
15 mammalian galectins have either one or two conserved carbohydrate recognition …

In addition to the classical functions of the Golgi in membrane transport and glycosylation,
the Golgi apparatus of mammalian cells is now recognised to contribute to the regulation of …

Tumours exist in a hypoxic microenvironment and must limit excessive oxygen consumption.
Hypoxia-inducible factor (HIF) controls mitochondrial oxygen consumption, but how/if …

Just as oncogene activation and tumor suppressor loss are hallmarks of tumor development,
emerging evidence indicates that tumor microenvironment-mediated changes in …

Galectins are a family of β-galactoside-binding lectins carrying at least one consensus
sequence in the carbohydrate-recognition domain. Properties of glycosylated ligands, such …

De novo uridine-diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis requires
glucose, glutamine, acetyl-CoA and uridine, however GlcNAc salvaged from glycoconjugate …

For several decades, glycoprotein biologics have been successfully produced from Chinese
hamster ovary (CHO) cells. The therapeutic efficacy and potency of glycoprotein biologics …

In vertebrate cells the Golgi consists of individual stacks fused together into a compact
ribbon structure. The function of the ribbon structure of the Golgi has only begun to be …

Background Changes in protein glycosylation are widely observed in tumor cells. N-glycan
branching through adding β1, 6-linked N-acetylglucosamine (β1, 6-GlcNAc) to an α1, 6 …