Biomedical engineers are at the forefront of developing novel treatments to improve human
health, however, many products fail to translate to clinical implementation. In vivo pre-clinical …

Decellularized xenografts are an inherent component of regenerative medicine. Their
preserved structure, mechanical integrity and biofunctional composition have well …

Cardiovascular diseases hold the highest mortality rate among other illnesses which reveals
the significance of current limitations in common therapies. Three-dimensional (3D) …

The treatment of cardiac alterations is still nowadays a dramatic issue in the cardiosurgical
practice. Synthetic materials applied in this surgery have failed in their long-term therapeutic …

Introduction Many biomaterials are used in cardio-thoracic surgery with good short-term
results. However, calcification, dehiscence, and formation of scar tissue are reported. The …

Synthetic replacement grafts for heart valves and small-diameter blood vessels such as
coronary arteries have the potential to circumvent many of the limitations of currently …

Background: Pericardium tissue allograft can be used for surgical repair in several
procedures. One of the tissue engineering strategies is the process of decellularization. This …

Body membranes are thin sheets/layers of cells or tissues which cover the surface of internal
organs, the outside of the body and lines various body cavities. These membranes are …

The immune response due to Galα1, 3-Galβ1–4GlcNAc-R (α-Gal) epitopes is an important
factor in bioprosthetic heart valve failure. The aim of this study was to evaluate the immune …

Decellularized porcine pericardium has many applications in the cardiovascular field for its
excellent properties. The peritoneum is a single-layer bio-dialysis membrane with many …