Functional and structural connectivity measures, as assessed by means of functional and
diffusion MRI, are emerging as potential intermediate biomarkers for Alzheimer disease (AD) …

Frontotemporal dementia (FTD), the second most common type of presenile dementia, is a
heterogeneous neurodegenerative disease characterized by progressive behavioural …

Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …

The characteristics of early and mild disease in primary progressive aphasia are poorly
understood. This report is based on 25 patients with aphasia quotients> 85%, 13 of whom …

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …

Neural network breakdown is a key issue in neurodegenerative disease, but the
mechanisms are poorly understood. Here we investigated patterns of brain atrophy …

Objective: We aimed to investigate whether cognitive deficits and structural and functional
connectivity changes can be detected before symptom onset in a large cohort of carriers of …

Developing and validating sensitive biomarkers for the presymptomatic stage of familial
frontotemporal dementia is an important step in early diagnosis and for the design of future …

Frontotemporal dementia (FTD) is a genetically and pathologically heterogeneous disorder
characterized by personality changes, language impairment, and deficits of executive …

Objective Common neurological diseases or injuries that can affect the right hemisphere,
including stroke, traumatic brain injury, and frontotemporal dementia, disrupt emotional …