Clinical progress in the field of HER2-positive breast cancer therapy has been dramatically
improved by understanding of the immune regulatory mechanisms of tumor …

During tumor development and progression, intrinsic and extrinsic factors trigger
endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the …

Peptide-based vaccines are attractive approaches for cancer immunotherapy; but the
success of these vaccines in clinical trials have been limited. Our goal is to improve immune …

The importance of HSPs themselves in antigen presentation and cross-presentation remains
controversial. Most studies agree that as part of their molecular chaperone function, HSPs …

Background: HSP90B1, a member of the heat-shock protein 90 family, plays a vital role as a
molecular chaperone for oncogenes and stimulates tumour growth. However, its role in …

The immunogenic properties of heat shock proteins (HSPs) have prompted investigations
into their application as immuno-modulatory agents. HSPs have been used as potent …

DNA vaccines have emerged as a promising approach for generating antigen-specific
immunotherapy. However, due to their low immunogenicity, there is a need to enhance DNA …

The Her2 is one of tumor-associated antigens (TAA), regarded as an ideal target of
immunotherapy. DNA encoding full-length or truncated rat Her2/neu have shown protective …

It has been frequently reported that gp96 acts as a strong biologic adjuvant. Some studies
have even investigated adjuvant activity of the gp96 C-or N-terminal domain. The …

In addition to their conventional chaperon activity, numerous studies have reported that heat
shock protein 70 (HSP0) exhibit immune properties and especially the capacity (i) to induce …