VEGF (vascular endothelial growth factor) and fibrotic lung disease

SL Barratt, VA Flower, JD Pauling, AB Millar - International Journal of …, 2018 - mdpi.com
Interstitial lung disease (ILD) encompasses a group of heterogeneous diseases
characterised by varying degrees of aberrant inflammation and fibrosis of the lung …

Treatable traits in systemic sclerosis

F Amati, G Bongiovanni, A Tonutti, F Motta… - Clinical Reviews in …, 2023 - Springer
Systemic sclerosis (SSc) is a chronic systemic disease within the spectrum of connective
tissue diseases, specifically characterized by vascular abnormalities and inflammatory and …

Long-term efficacy of B cell depletion therapy on lung and skin involvement in diffuse systemic sclerosis

SL Bosello, G De Luca, M Rucco, G Berardi… - Seminars in arthritis and …, 2015 - Elsevier
Objectives To assess the long-term efficacy and safety of single and multiple courses of
rituximab therapy in systemic sclerosis (SSc) patients with and without lung disease …

Nailfold videocapillaroscopy and serum VEGF levels in scleroderma are associated with internal organ involvement

M De Santis, A Ceribelli, F Cavaciocchi, C Crotti… - Autoimmunity …, 2016 - Springer
Purpose Nailfold videocapillaroscopy (NVC) identifies the microvascular hallmarks of
systemic sclerosis (SSc) and vascular endothelial growth factor (VEGF) and may play a …

Towards a unified approach in autoimmune fibrotic signalling pathways

M Sisto, S Lisi - International Journal of Molecular Sciences, 2023 - mdpi.com
Autoimmunity is a chronic process resulting in inflammation, tissue damage, and
subsequent tissue remodelling and organ fibrosis. In contrast to acute inflammatory …

Association between nailfold capillaroscopy findings and pulmonary function tests in patients with systemic sclerosis

I Castellví, CP Simeón-Aznar, M Sarmiento… - The Journal of …, 2015 - jrheum.org
Objective. To determine whether there is an association between different capillaroscopic
findings and pulmonary function tests in systemic sclerosis (SSc). Methods. We did a …

Dysregulation of angiogenic homeostasis in systemic sclerosis

HM Farouk, SH Hamza, SA El Bakry… - International Journal …, 2013 - Wiley Online Library
Background Systemic sclerosis (SS c) is a connective tissue disorder characterized by tissue
hypoxia and excessive fibrosis of skin and internal organs. Objective To evaluate the …

Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study

S Reiseter, Ø Molberg, R Gunnarsson, MB Lund… - Arthritis research & …, 2015 - Springer
Abstract Introduction Systemic sclerosis (SSc) and mixed connective tissue disease (MCTD)
are chronic immune-mediated disorders complicated by vascular organ damage. The aim of …

Vascular endothelial growth factor as a potential biomarker in systemic sclerosis: a systematic review and meta-analysis

A Zinellu, AA Mangoni - Frontiers in Immunology, 2024 - frontiersin.org
Introduction Systemic sclerosis (SSc), a chronic autoimmune condition, is characterized by
microvascular dysfunction, ineffective angiogenesis, and fibrosis. The identification of robust …

Systemic sclerosis associated interstitial lung disease: a comprehensive overview

JA Mackintosh, A Stainer, JL Barnett… - … in respiratory and …, 2019 - thieme-connect.com
Interstitial lung disease (ILD) is a common complication of systemic sclerosis (SSc). SSc-ILD
adversely impacts quality of life and is currently the leading cause of death in this …