Chronic health conditions (CHCs) are common and associated with functional limitations.
Acceptance and commitment therapy (ACT) shows promise in improving functioning, quality …

Abstract Background Cluster-randomized trials (CRTs) involve randomizing groups of
individuals (eg hospitals, schools or villages) to different interventions. Various approaches …

Advancing scientific discovery requires investigators to embrace research practices that
increase transparency and disclosure about materials, methods, and outcomes. Several …

Background Considered one of the highest levels of evidence, results of randomized
controlled trials (RCTs) remain an essential building block in mental health research. They …

Recent work has reported that respiratory audio-trained AI classifiers can accurately predict
SARS-CoV-2 infection status. However, it has not yet been determined whether such model …

This article is a systematic review and meta-analysis of RCTs to synthesize the current
evidence on the effects of ACT on insomnia and sleep quality. This is the first meta-analysis …

OBJECTIVE: To update the evidence on the effectiveness of exercise interventions to
prevent episodes of neck pain. DESIGN: Systematic review with meta-analysis …

Statistical regression models are used for predicting outcomes based on the values of some
predictor variables or for describing the association of an outcome with predictors. With a …

Background Novel precision medicine therapeutics target increasingly granular,
genomically-defined populations. Rare sub-groups make it challenging to study within a …

Many trials use stratified randomisation, where participants are randomised within strata
defined by one or more baseline covariates. While it is important to adjust for stratification …