Imidazole ring is an important five‐membered aromatic heterocycle widely present in natural
products and synthetic molecules. The unique structural feature of imidazole ring with …

Human aromatase catalyzes the synthesis of estrogen from androgen with high substrate
specificity. For the past 40 years, aromatase has been a target of intense inhibitor discovery …

It is a challenging task to design target-specific and less toxic non-steroidal aromatase
inhibitors (NSAIs) though the modeling studies for designing anti-aromatase molecules have …

Abstract A series of 1, 4-disubstituted-1, 2, 3-triazoles (13–35) containing sulfonamide
moiety were synthesized and evaluated for their aromatase inhibitory effects. Most triazoles …

Methylation of DNA and histone proteins are mutually involved in the epigenetic regulation
of gene expression mediated by DNA methyltransferases (DNMTs) and histone …

Flavonoids are phenolic compounds, secondary metabolites of plants that cause several
benefits to our health, including helping the treatment against cancer. These …

Aromatase inhibitors (AIs) represent a promising therapeutic class of anticancer agents
against estrogen receptor-positive breast cancer. Bioactivity data on pIC 50 of 973 AIs were …

Steroidal and non-steroidal aromatase inhibitors target the suppression of estrogen
biosynthesis in the treatment of breast cancer. Researchers have increasingly focused on …

Aromatase is a rate-limiting enzyme for estrogen biosynthesis that is overproduced in breast
cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed …

In this study, we have employed in silico methodology combining double pharmacophore
based screening, molecular docking, and ADME/T filtering to identify dual binding site …