Modern quantitative image analysis techniques have enabled high-throughput, high-content
imaging experiments. Image-based profiling leverages the rich information in images to …

Highlights•Hematological malignancies comprise 1.2 million new cases annually
worldwide.•Current treatment options are limited by cancer cell resistance and relapse …

High-content image-based assays have fueled significant discoveries in the life sciences in
the past decade (2013–2023), including novel insights into disease etiology, mechanism of …

Quantitative morphological phenotyping (QMP) is an image-based method used to capture
morphological features at both the cellular and population level. Its interdisciplinary nature …

Genetics-based approaches can enable drug target identification in human cells. In this
issue of Cell Chemical Biology, Nguyen et al. 1 use inducible degradation of a mismatch …

Pyroptosis represents one type of Programmed Cell Death (PCD). It is a form of inflammatory
cell death that is canonically defined by caspase-1 cleavage and Gasdermin-mediated …

Neurofibromatosis type 1 (NF1) is a multi-system, autosomal dominant genetic disorder
driven by the systemic loss of the NF1 protein neurofibromin. Loss of neurofibromin in …

Glioblastoma (GBM) is an aggressive brain cancer with a poor survival rate. Despite
hundreds of clinical trials, there is no effective targeted therapy. Glioblastoma stem cells …