Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

Abstract The 5-HT 2C receptor (R) displays a widespread distribution in the CNS and is
involved in the action of 5-HT in all brain areas. Knowledge of its functional role in the CNS …

Monofluoroalkenes have found wide application in organic chemistry, medicinal chemistry,
and materials science. This review summarizes the most recent advances made regarding …

The selective 5-HT2C receptor agonist lorcaserin, in conjunction with lifestyle modification,
was approved by the FDA in 2012 for weight management. It has been marketed in the US …

A Pd-catalyzed ring-opening sulfonylation of gem-difluorocyclopropanes is reported. This
protocol involves C–C bond cleavage, β-F elimination, and allylic coupling to form …

The GPR139 receptor is an orphan G-protein-coupled receptor (GPCR) mainly found in the
central nervous system and is a potential therapeutic target for the treatment of …

Serotonin (5-HT) 5-HT2C receptor (5-HT2CR) is recognized as a critical mediator of
diseaserelated pathways and behaviors based upon actions in the central nervous system …

Abstract Serotonin (5-HT) receptors are proteins involved in various neurological and
biological processes, such as aggression, anxiety, appetite, cognition, learning, memory …

All FDA-approved antipsychotic drugs (APDs) target primarily dopamine D 2 or serotonin (5-
HT 2A) receptors, or both; however, these medications are not universally effective, they may …

G-protein coupled receptors (GPCRs) are considered important therapeutic targets due to
their pathophysiological significance and pharmacological relevance. Class A receptors …