Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

Myofibrillar proteins exist as multiple isoforms that derive from multigene (isogene) families.
Additional isoforms, including products of tropomyosin, myosin light chain 1 fast, troponin T …

In skeletal muscle, nebulin stabilizes and regulates the length of thin filaments, but the
underlying mechanism remains nebulous. In this work, we used cryo–electron tomography …

The lung is an architecturally complex organ comprising a heterogeneous mixture of various
epithelial and mesenchymal lineages. We use single-cell RNA sequencing and signaling …

Contractile and energetic properties of human skeletal muscle have been studied for many
years in vivo in the body. It has been, however, difficult to identify the specific role of muscle …

The Z-disc, appearing as a fine dense line forming sarcomere boundaries in striated
muscles, when studied in detail reveals crosslinked filament arrays that transmit tension and …

Cardiac muscle cells are equipped with specialized biochemical machineries for the rapid
generation of force and movement central to the work generated by the heart. During each …

Muscles are essential for movement and heart function. Contraction and relaxation of
muscles rely on the sliding of two types of filaments—the thin filament and the thick myosin …

Striated muscle sarcomeres in vertebrates comprise ordered arrays of actin and myosin
filaments, organized by an elaborate protein scaffold. Recent innovative work in a number of …

The formation of perfectly aligned myofibrils in striated muscle represents a dramatic
example of supramolecular assembly in eukaryotic cells. Recently, considerable progress …