Ski and the closely related SnoN were discovered as oncogenes by their ability to transform
chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and …

The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating
many physiological processes in development and tissue homeostasis. The TGF-β signaling …

Transforming growth factor (TGF)-beta is a central stimulus of the events leading to chronic
progressive kidney disease, having been implicated in the regulation of cell proliferation …

The five members of the inhibitor of growth (ING) gene family have garnered significant
interest due to their putative roles as tumor suppressors. However, the precise role (s) of …

Over the last decade, imaging as a detection mode for cell based assays has opened a new
world of opportunities to measure “phenotypic endpoints” in both current and developing …

Cancer cells accumulate genetic and epigenetic changes that alter gene expression to drive
tumorigenesis. Epigenetic silencing of tumor suppressor, cell cycle, differentiation and DNA …

In hibitor of G rowth 1 (ING1) was identified and characterized as a “candidate” tumor
suppressor gene in 1996. Subsequently, four more genes, also characterized as “candidate” …

Inhibitor of growth (ING) family proteins have been defined as candidate tumor suppressors
for more than a decade. Recent emerging results using siRNA and knockout mice are …

In the confocal mode, Raman microspectroscopy can profile the biochemical content of
biological cells at a subcellular level, and any changes to it by exogenous agents, such as …

The proper development and patterning of axons, dendrites, and synapses is essential for
the establishment of accurate neuronal circuits in the brain. A major goal in neurobiology is …