Systemic immune monitoring is a crucial clinical tool for disease early diagnosis, prognosis
and treatment planning by quantitative analysis of immune cells. However, conventional …

Cell plasticity and neuroendocrine differentiation in prostate and lung adenocarcinomas are
one of the major reasons for therapeutic resistance to targeted therapy. Whether and how …

Cell lineage plasticity is one of the major causes for the failure of targeted therapies in
various cancers. However, the driver and actionable drug targets in promoting cancer cell …

Prostate cancer liver metastasis (PCLM), seen in upwards of 25% of metastatic castration-
resistant PC (mCRPC) patients, is the most lethal site of mCRPC with a median overall …

Iron is an essential biomineral in the human body. Here, we describe a subset of iron-loaded
cancer-associated fibroblasts, termed as FerroCAFs, that utilize iron to induce …

Great attention is paid to the role of androgen receptor (AR) as a central transcriptional factor
in driving the growth of prostate cancer (PCa) epithelial cells. However, the understanding of …

Organoid technology, as a revolutionary biomedical tool, has shown immense potential in
haematological research in recent years. By using three‐dimensional (3D) cell culture …

Liver metastases from prostate cancer are associated with an aggressive disease course
and poor prognosis. Results from autopsy studies indicate a liver metastasis prevalence of …

Cancer is a highly heterogeneous disease, and thus treatment responses vary greatly
between patients. To improve therapy efficacy and outcome for cancer patients, more …

Introduction: Prostate cancer liver metastasis (PCLM), seen in upwards of 25% of PC
patients, is the most lethal PC metastatic site, with a median overall survival of 10-14 …