Chemopreventive mechanisms of amentoflavone: recent trends and advancements

HS Tuli, H Joshi, K Vashishth, S Ramniwas… - Naunyn-Schmiedeberg's …, 2023 - Springer
In parallel to the continuous rise of new cancer cases all over the world, the interest of
scientific community in natural anticancer agents has steadily been increased. In the past …

Role of flavonoids in inhibiting triple-negative breast cancer

S Wang, K Wang, C Li, J Chen, X Kong - Frontiers in Pharmacology, 2024 - frontiersin.org
Increasing incidences of metastasis or recurrence (or both) in triple-negative breast cancer
(TNBC) are a growing concern worldwide, as these events are intricately linked to higher …

Amentoflavone mitigates doxorubicin-induced cardiotoxicity by suppressing cardiomyocyte pyroptosis and inflammation through inhibition of the STING/NLRP3 …

G Fang, X Li, F Yang, T Huang, C Qiu, K Peng, Z Wang… - Phytomedicine, 2023 - Elsevier
Background Doxorubicin (DOX) is a potent anticancer chemotherapeutic agent whose
clinical application is substantially constrained by its cardiotoxicity. The pathophysiology of …

Amentoflavone attenuates cell proliferation and induces ferroptosis in human gastric cancer by miR‐496/ATF2 axis

F Tang, Y Xu, E Gao, W Zhang, F Zhang… - Chemical Biology & …, 2023 - Wiley Online Library
Amentoflavone (AF) is a natural multifunctional biflavonoid that has been revealed to
possess multiple biological activities, including anticancer activity. Here, this work focused …

Solasodine suppress MCF7 breast cancer stem-like cells via targeting Hedgehog/Gli1

J Chen, D Ma, C Zeng, LV White, H Zhang, Y Teng… - Phytomedicine, 2022 - Elsevier
Background Recently, a novel therapy to treat cancer has been to target cancer stem-like
cells (CSCs). The aim of this study was to investigate the effect of solasodine, a steroidal …

Anti‑epileptic mechanism of isopimaric acid from Platycladi cacumen based on network pharmacology, molecular docking and biological validation

Y Wang, Y Wang, C Li, D Liu… - Experimental and …, 2024 - spandidos-publications.com
Platycladi cacumen (PC) is derived from the dry twigs and leaves of Platycladi orientalis (L.)
Franco and exerts anti-epileptic effects. However, its mechanism of action remains unknown …

阿曼托双黄酮通过JAK2-STAT3 通路影响甲状腺癌SW579 细胞的增殖和凋亡.

马涛, 王红梅, 赵婷, 黄凌燕… - Chinese Journal of …, 2023 - search.ebscohost.com
目的: 探讨阿曼托双黄酮(AF) 对甲状腺癌SW579 细胞中JAK2-STAT3 通路活化及其细胞增殖和
凋亡的影响. 方法: 用0, 50,100,150,200 μmol/L 的AF 处理SW579 细胞24, 48, 72 h, 采用CCK …

Amentoflavone for treating cardiocerebrovascular diseases and neurological disorders

H Zhang, Y Ban, D Li, G Wang, J Gu… - Frontiers in …, 2024 - frontiersin.org
Amentoflavone (AME) is a flavonoid compound found in over 120 plants. Its extensive
pharmacological activity for treating cardiocerebrovascular diseases and neurological …

The role of Ginkgo Folium on antitumor: Bioactive constituents and the potential mechanism

D Hu, HJ Wang, LH Yu, ZR Guan, YP Jiang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Ginkgo biloba L. is a well-known and highly regarded
resource in Chinese traditional medicine due to its effectiveness and safety. Ginkgo Folium …

Garcinone C suppresses tumorsphere formation and invasiveness by hedgehog/gli1 signaling in colorectal cancer stem-like cells

Y Zhou, S Qiu, JT Kim, SB Lee, HJ Park… - Journal of Agricultural …, 2022 - ACS Publications
Hyperactivation of hedgehog signaling occurs in colorectal cancer stem-like cells (CSCs), a
rare subpopulation, potentially involved in metastasis, chemotherapy resistance, and cancer …