Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural
diversity and fulfilling various functions mediated by thousands of interactions in the …

Chirality is a universal phenomenon in nature and an essential attribute of life systems.
Chiral recognition has very important research value in many fields. Amino acids and other …

Glycosaminoglycans (GAGs) are abundant, ubiquitous carbohydrates in biology, yet their
structural complexity has limited an understanding of their biological roles and structure …

Heparin (HP) and heparan sulfate (HS) are linear, anionically charged polysaccharides well-
known for their diverse biological activities. While HP is generally localized in mast cells and …

Heparan sulfate (HS) has multifaceted biological activities. To date, no libraries of HS
oligosaccharides bearing systematically varied sulfation structures are available owing to …

Sulfated glycans are involved in many biological processes, making well-defined sulfated
oligosaccharides highly sought molecular probes. These compounds are a considerable …

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of
carbohydrates and underpin considerable repertoires of biological importance. As such …

Herein, we report the synthesis and biological evaluation of a novel series of heparinoid
amphiphiles as inhibitors of heparanase and SARS-CoV-2. By employing a tailor-made …

Fondaparinux, a clinically approved anticoagulant pentasaccharide for the treatment of
thrombotic diseases, displays better efficacy and biosafety than other heparin-based …

Heparan sulfate (HS) is a complex, polyanionic polysaccharide ubiquitously expressed on
cell surfaces and in the extracellular matrix. HS interacts with numerous proteins to mediate …