Developments in tetrazole chemistry (2009–16)
VA Ostrovskii, EA Popova, RE Trifonov - Advances in heterocyclic chemistry, 2017 - Elsevier
This short review compiles the main results of the studies in tetrazole chemistry published in
the period 2009–2016. Attention is directed to the structure, reactivity, synthetic problems …
the period 2009–2016. Attention is directed to the structure, reactivity, synthetic problems …
A review of syntheses of 1, 5-disubstituted tetrazole derivatives
This report provides a brief overview of the various representative literature procedures for
the synthesis of 1, 5-disubstituted tetrazoles (1, 5-DSTs) and fused 1, 5-disubstituted …
the synthesis of 1, 5-disubstituted tetrazoles (1, 5-DSTs) and fused 1, 5-disubstituted …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Recent developments in the synthesis of tetrazoles and their pharmacological relevance
S Leyva-Ramos, J Cardoso-Ortiz - Current Organic Chemistry, 2021 - ingentaconnect.com
The heterocycle ring tetrazole is an important moiety relevant to medicinal chemistry since it
is present in some drugs with clinical importance. Its primary biological activity is being a …
is present in some drugs with clinical importance. Its primary biological activity is being a …
Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and …
Nineteen new compounds containing tetrazole and/or cyanamide moiety have been
designed and synthesised. Their structures were confirmed using spectroscopic methods …
designed and synthesised. Their structures were confirmed using spectroscopic methods …
Selective cyclooxygenase-2 inhibitors: A review of recent chemical scaffolds with promising anti-inflammatory and COX-2 inhibitory activities
Abstract Selective cyclooxygenase-2 (COX-2) inhibitors have exhibited notable medicinal
importance. In recent years, the discovery of new anti-inflammatory agents as selective COX …
importance. In recent years, the discovery of new anti-inflammatory agents as selective COX …
Synthesis, Biological Activity, and Molecular Modeling Studies of Pyrazole and Triazole Derivatives as Selective COX‐2 Inhibitors
M Assali, M Abualhasan, H Sawaftah… - Journal of …, 2020 - Wiley Online Library
Series of diaryl‐based pyrazole and triazole derivatives were designed and synthesized in a
facile synthetic approach in order to produce selective COX‐2 inhibitor. These series of …
facile synthetic approach in order to produce selective COX‐2 inhibitor. These series of …
An expeditious approach to tetrazoles from amides utilizing phosphorazidates
K Ishihara, T Shioiri, M Matsugi - Organic Letters, 2020 - ACS Publications
A novel method was developed for the synthesis of tetrazoles from amides utilizing diphenyl
phosphorazidate or bis (p-nitrophenyl) phosphorazidate as both the activator of amide …
phosphorazidate or bis (p-nitrophenyl) phosphorazidate as both the activator of amide …
Synthesis of multiply arylated heteroarenes, including bioactive derivatives, via palladium-catalyzed direct C–H arylation of heteroarenes with (pseudo) aryl halides or …
This review with 387 references covers the literature until the end of November 2013 on the
synthesis of multiply arylated heteroarenes via highly selective palladium-catalyzed direct C …
synthesis of multiply arylated heteroarenes via highly selective palladium-catalyzed direct C …
Antioxidant, DNA interaction, VEGFR2 kinase, topoisomerase I and in vitro cytotoxic activities of heteroleptic copper (II) complexes of tetrazolo [1, 5-a] pyrimidines and …
A Haleel, D Mahendiran, V Veena, N Sakthivel… - Materials Science and …, 2016 - Elsevier
A series of heteroleptic mononuclear copper (II) complexes of the type [Cu (L 1–3)(diimine)]
ClO 4 (1–6) containing three tetrazolo [1, 5-a] pyrimidine core ligands, ethyl 5-methyl-7-(2 …
ClO 4 (1–6) containing three tetrazolo [1, 5-a] pyrimidine core ligands, ethyl 5-methyl-7-(2 …