Single-strand break end resection in genome integrity: mechanism and regulation by APE2
DNA single-strand breaks (SSBs) occur more than 10,000 times per mammalian cell each
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …
day, representing the most common type of DNA damage. Unrepaired SSBs compromise …
[HTML][HTML] Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR
H Schuhwerk, T Brabletz - Seminars in Cancer Biology, 2023 - Elsevier
TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
AA Demin, K Hirota, M Tsuda, M Adamowicz… - Molecular cell, 2021 - cell.com
Mammalian DNA base excision repair (BER) is accelerated by poly (ADP-ribose)
polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect …
polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect …
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
The response to poly (ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous
recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It …
recombination (HR) DNA repair and the abundance of lesions that trap PARP enzymes. It …
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certain
DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA …
DNA lesions. ALC1/CHD1L is a nucleosome-remodeling enzyme that responds to DNA …
The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment
Poly (ADP-ribose) polymerase (PARP) inhibitors are used in the treatment of BRCA-deficient
cancers, with treatments currently extending toward other homologous recombination …
cancers, with treatments currently extending toward other homologous recombination …
Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins
N Kumar, AF Theil, V Roginskaya, Y Ali… - Nature …, 2022 - nature.com
UV-DDB, consisting of subunits DDB1 and DDB2, recognizes UV-induced photoproducts
during global genome nucleotide excision repair (GG-NER). We recently demonstrated a …
during global genome nucleotide excision repair (GG-NER). We recently demonstrated a …
The oncogenic helicase ALC1 regulates PARP inhibitor potency by trapping PARP2 at DNA breaks
C Blessing, IK Mandemaker, C Gonzalez-Leal… - Molecular Cell, 2020 - cell.com
The anti-tumor potency of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) has
been linked to trapping of PARP1 on damaged chromatin. However, little is known about …
been linked to trapping of PARP1 on damaged chromatin. However, little is known about …
Nucleolytic processing of abasic sites underlies PARP inhibitor hypersensitivity in ALC1-deficient BRCA mutant cancer cells
N Ramakrishnan, TM Weaver, LN Aubuchon… - Nature …, 2024 - nature.com
Clinical success with poly (ADP-ribose) polymerase inhibitors (PARPi) is impeded by
inevitable resistance and associated cytotoxicity. Depletion of Amplified in Liver Cancer 1 …
inevitable resistance and associated cytotoxicity. Depletion of Amplified in Liver Cancer 1 …
Recurrent chromosome reshuffling and the evolution of neo-sex chromosomes in parrots
The karyotype of most birds has remained considerably stable during more than 100 million
years' evolution, except for some groups, such as parrots. The evolutionary processes and …
years' evolution, except for some groups, such as parrots. The evolutionary processes and …