Heart failure secondary to myocardial infarction (MI) remains a major source of morbidity
and mortality. Long-term outcome after MI can be largely be defined in terms of its impact on …

Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart
disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI …

Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are
also encountered in∼ 1% of the general population, where they may be silent, perhaps …

Transgenic and knockout mice can be used to study the genes and basic mechanisms
involved in heart disease, and have therefore assumed a central role in modern cardiac …

Fibrosis is the formation or development of excess fibrous connective tissue (largely type I
collagen) in a tissue as a result of a reparative or reactive process. Fibrosis, or scarring, is a …

Purpose: To prospectively evaluate a gadolinium-based collagen-targeting contrast agent,
EP-3533, for in vivo magnetic resonance (MR) imaging of myocardial fibrosis in a mouse …

The ability to trace or identify specific molecules within a specific anatomic location provides
insight into metabolic pathways, tissue components, and tracing of solute transport …

The cardiac muscle architecture lies at the basis of the mechanical and electrical properties
of the heart, and dynamic alterations in fiber structure are known to be of prime importance …

Background—The role of the angiotensin II type 2 receptor (AT2-R) in left ventricular (LV)
remodeling may depend on the underlying stimulus. We hypothesized that cardiac AT2-R …

Purpose To establish fast, high‐resolution in vivo cine magnetic resonance imaging (cine‐
MRI) on a vertical 11.7‐T MR system and to investigate the stability of normal and failing …