Yersinia pestis: the natural history of plague

R Barbieri, M Signoli, D Chevé… - Clinical microbiology …, 2020 - Am Soc Microbiol
SUMMARY The Gram-negative bacterium Yersinia pestis is responsible for deadly plague, a
zoonotic disease established in stable foci in the Americas, Africa, and Eurasia. Its …

Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics

CE Demeure, O Dussurget, G Mas Fiol… - Genes & …, 2019 - nature.com
Plague is a vector-borne disease caused by Yersinia pestis. Transmitted by fleas from
rodent reservoirs, Y. pestis emerged< 6000 years ago from an enteric bacterial ancestor …

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

W Barrie, Y Yang, EK Irving-Pease, KE Attfield… - Nature, 2024 - nature.com
Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most
prevalent in Northern Europe. Although it is known that inherited risk for MS is located within …

100 ancient genomes show repeated population turnovers in Neolithic Denmark

ME Allentoft, M Sikora, A Fischer, KG Sjögren… - Nature, 2024 - nature.com
Major migration events in Holocene Eurasia have been characterized genetically at broad
regional scales,,–. However, insights into the population dynamics in the contact zones are …

Stone Age Yersinia pestis genomes shed light on the early evolution, diversity, and ecology of plague

A Andrades Valtueña, GU Neumann… - Proceedings of the …, 2022 - National Acad Sciences
The bacterial pathogen Yersinia pestis gave rise to devastating outbreaks throughout
human history, and ancient DNA evidence has shown it afflicted human populations as far …

Ancient pathogen genomics as an emerging tool for infectious disease research

MA Spyrou, KI Bos, A Herbig, J Krause - Nature Reviews Genetics, 2019 - nature.com
Over the past decade, a genomics revolution, made possible through the development of
high-throughput sequencing, has triggered considerable progress in the study of ancient …

The four black deaths

MH Green - The American Historical Review, 2020 - academic.oup.com
Abstract The Black Death, often called the largest pandemic in human history, is
conventionally defined as the massive plague outbreak of 1346 to 1353 ce that struck the …

Early contact between late farming and pastoralist societies in southeastern Europe

S Penske, AB Rohrlach, A Childebayeva… - Nature, 2023 - nature.com
Archaeogenetic studies have described two main genetic turnover events in prehistoric
western Eurasia: one associated with the spread of farming and a sedentary lifestyle starting …

Ancient Yersinia pestis genomes from across Western Europe reveal early diversification during the First Pandemic (541–750)

M Keller, MA Spyrou, CL Scheib… - Proceedings of the …, 2019 - National Acad Sciences
The first historically documented pandemic caused by Yersinia pestis began as the
Justinianic Plague in 541 within the Roman Empire and continued as the so-called First …

Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe

G Kerner, AL Neehus, Q Philippot, J Bohlen, D Rinchai… - Cell genomics, 2023 - cell.com
Ancient genomics can directly detect human genetic adaptation to environmental cues.
However, it remains unclear how pathogens have exerted selective pressures on human …