Mining genomes to illuminate the specialized chemistry of life

MH Medema, T de Rond, BS Moore - Nature Reviews Genetics, 2021 - nature.com
All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Terpene synthases as metabolic gatekeepers in the evolution of plant terpenoid chemical diversity

PS Karunanithi, P Zerbe - Frontiers in plant science, 2019 - frontiersin.org
Terpenoids comprise tens of thousands of small molecule natural products that are widely
distributed across all domains of life. Plants produce by far the largest array of terpenoids …

Plant specialized metabolism: diversity of terpene synthases and their products

ME Bergman, N Dudareva - Current Opinion in Plant Biology, 2024 - Elsevier
Terpenoids are ubiquitous to all kingdoms of life and are one of the most diverse groups of
compounds, both structurally and functionally. Despite being derived from common …

Evolutionary dynamics of natural product biosynthesis in bacteria

MG Chevrette, K Gutiérrez-García… - Natural product …, 2020 - pubs.rsc.org
Covering: 2008 up to 2019 The forces of biochemical adaptive evolution operate at the level
of genes, manifesting in complex phenotypes and the global biodiversity of proteins and …

Chemical convergence between plants and insects: biosynthetic origins and functions of common secondary metabolites

F Beran, TG Köllner, J Gershenzon, D Tholl - New Phytologist, 2019 - Wiley Online Library
Despite the phylogenetic distance between plants and insects, these two groups of
organisms produce some secondary metabolites in common. Identical structures belonging …

Terpene biosynthesis in marine sponge animals

K Wilson, T de Rond, I Burkhardt… - Proceedings of the …, 2023 - National Acad Sciences
Sea sponges are the largest marine source of small-molecule natural products described to
date. Sponge-derived molecules, such as the chemotherapeutic eribulin, the calcium …

A comprehensive survey on the terpene synthase gene family provides new insight into its evolutionary patterns

SY Jiang, J Jin, R Sarojam… - Genome biology and …, 2019 - academic.oup.com
Terpenes are organic compounds and play important roles in plant growth and development
as well as in mediating interactions of plants with the environment. Terpene synthases (TPS …

Orthogonal Engineering of Biosynthetic Pathway for Efficient Production of Limonene in Saccharomyces cerevisiae

S Cheng, X Liu, G Jiang, J Wu, J Zhang… - ACS Synthetic …, 2019 - ACS Publications
Limonene, a plant-derived natural cyclic monoterpene, is widely used in the pharmaceutical,
food, and cosmetics industries. The conventional limonene biosynthetic (CLB) pathway in …

Function and structure of a terpene synthase encoded in a giant virus genome

Y Jung, T Mitsuhashi, S Sato, M Senda… - Journal of the …, 2023 - ACS Publications
Giant viruses are nonstandard viruses with large particles and genomes. While previous
studies have shown that their genomes contain various sequences of interest, their genes …

The Role of (E)-β-Farnesene in Tritrophic Interactions: Biosynthesis, Chemoreception, and Evolution

B Wang, E Jacquin-Joly, G Wang - Annual Review of …, 2024 - annualreviews.org
(E)-β-farnesene (EBF) stands out as a crucial volatile organic compound, exerting significant
influence on the complex interactions between plants, aphids, and predator insects. Serving …