Cholestasis is a common complication in liver diseases that triggers a proliferative response
of the biliary tree. Bile duct ligation (BDL) is a frequently used model of cholestasis in …

Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in
infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the …

Background Biliary atresia (BA) is difficult to distinguish from other causes of cholestasis. We
evaluated the use of liquid chromatography–mass spectroscopy (LC-MS) and bile acid …

In this paper, the features of ductular reaction (DR) and remodeling of the biliary tract are
discussed in models of total and selective biliary occlusion. It has been shown that the …

We previously described a selective bile duct ligation model to elucidate the process of
hepatic fibrogenesis in children with biliary atresia or intrahepatic biliary stenosis. Using this …

Background/purpose Biliary atresia and other liver biliary obstructions are relevant
conditions in pediatric surgery due to their progression to biliary cirrhosis and indication for …

Sepsis develops as a normal inflammatory response to various infections. It proceeds with
the picture of a complex heterogeneous syndrome, which often leads to the development of …

The advent of liver transplantation provided a treatment option for several pediatric terminal
liver diseases. In September 1989, we performed the first pediatric liver transplantation in a …

Bile duct ligation (BDL) can cause cholangitis, which is known to induce impaired Kupffer
cell (KC) function and increased oxygen consumption in a mouse model. It is important to …

Animal models play a pivotal role in biomedical research. Surgical rodent models are widely
used in the preclinical drug discovery process. A well-planned surgery with aseptic …