Objective: This review examines the best available evidence on the aetiology of childhood
acute non-traumatic coma in resource-poor countries (RPCs), discusses the challenges …

Admission records are seldom used in sub-Saharan Africa to delineate hospital catchments
for the spatial description of hospitalised disease events. We set out to investigate spatial …

Aim To investigate geographical change over time in the burden of neurological
impairments in school‐aged children in a demographic surveillance area. Method We …

Background Cerebral malaria is a rapidly developing encephalopathy caused by the
apicomplexan parasite Plasmodium falciparum. Drugs currently in use are associated with …

Background Although a substantial decline of Plasmodium falciparum infection is observed
in Africa following implementation of new control strategies, malaria is still considered as the …

Background In malaria-endemic areas, children presenting to hospitals with a decreased
level of consciousness remain a diagnostic dilemma. The definition of cerebral malaria in a …

Background Acute seizures are common in pediatric cerebral malaria (CM), but usual care
with phenobarbital risks respiratory suppression. We undertook studies of enteral …

The distribution of neurological disease-and the resources available for its diagnosis and
treatment-is very different in Africa. In addition, many of the diseases encountered, such as …

Objectives To assess whether viral, bacterial, metabolic, and autoimmune diseases are
missed by conventional diagnostics among children with severe acute encephalopathy in …

Clinical signs and symptoms of cerebral malaria in children are nonspecific and are seen in
other common encephalopathies in malaria-endemic areas. This makes accurate diagnosis …