Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …

Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism
as well as in cellular response to xenobiotics, cytokines, and bacterial invasion. Oxidative …

Reactive oxygen species (ROS), highly reactive molecules, are produced by living
organisms as a result ofnormal cellular metabolism and environmental factors, and can …

Although historically viewed as purely harmful, recent evidence suggests that reactive
oxygen species (ROS) function as important physiological regulators of intracellular …

The importance of PTEN in cellular function is underscored by the frequency of its
deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid …

The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated
manner with protein tyrosine kinases to control signalling pathways that underlie a broad …

PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …

Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS …

NADPH oxidase (Nox) has a dedicated function of generating reactive oxygen species
(ROS). Accumulating evidence suggests that Nox has an important role in signal …