MYB transcription factors are highly conserved from plants to vertebrates, indicating that
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …

Fig 2. Classification of granules in neutrophils. Peroxidase-positive (azurophilic or primary)
granules are characterized by the content of MPO and may be further divided based on their …

A domain of DNA designated N-myc is amplified 20-to 140-fold in human neuroblastoma
cell lines but not in cell lines from other tumor types. N-myc has now been found to be …

The c-myb proto-oncogene encodes a sequence-specific DNA-binding protein. To better
understand its normal biological function, we have altered the c-myb gene by homologous …

The transcription factor MYB has a key role as a regulator of stem and progenitor cells in the
bone marrow, colonic crypts and a neurogenic region of the adult brain. It is in these …

The myb gene family consists of three members, named A, B and c-myb which encode
nuclear proteins that function as transcriptional transactivators. Proteins encoded by these …

Following its highly successful and well-respected first edition, this thoroughly revised
edition offers much more! Edited and authored by leading authorities in hematology, this …

Publisher Summary The field of experimental hematology has advanced dramatically since
the development of the clonal culture assay in the mid-1960s. This technique proved to be …

A prominent phenotypic abnormality of human acute myelogenous leukemia cells is the
inability of the cells to differentiate to functional mature cells; instead, the cells are blocked at …

CCAAT/enhancer binding protein α (C/EBPα) is an integral factor in the granulocytic
developmental pathway, as myeloblasts from C/EBPα-null mice exhibit an early block in …