The AML treatment landscape has significantly changed in recent years with the approval of
targeted therapies in the front-line and relapsed/refractory settings, including inhibitors of …

Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …

Although outcomes of children and adolescents with newly diagnosed acute myeloid
leukemia (AML) have improved significantly over the past two decades, more than one-third …

Purpose: The purpose of the study was to design a pan-cancer gene panel for childhood
malignancies and validate it using clinically characterized patient samples. Experimental …

Pediatric acute myeloid leukemia (pAML) is characterized by heterogeneous cellular
composition, driver alterations and prognosis. Characterization of this heterogeneity and …

Oncogenic fusions formed through chromosomal rearrangements are hallmarks of
childhood cancer that define cancer subtype, predict outcome, persist through treatment …

UBTF tandem duplications (UBTF-TDs) have recently emerged as a recurrent alteration in
pediatric and adult acute myeloid leukemia (AML). UBTF-TD leukemias are characterized by …

Tandem duplications (TDs) of the UBTF gene have been recently described as a recurrent
alteration in pediatric acute myeloid leukemia (AML). Here, by screening 1946 newly …

Aberrant expression of HOX and MEIS1 family genes, as seen in KMT2A-rearranged,
NUP98-rearranged, or NPM1-mutated leukemias leads to arrested differentiation and …

Simple Summary Owing to the 40-year worldwide efforts for improving diagnosis and
therapy for acute myeloid leukemia (AML), the second most common type of leukemia in …