Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …

Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

Abstract Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset
Alzheimer's disease (AD). Conditions of stress or injury induce APOE expression within …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand
for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and …

Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …

Microglia are specialized parenchymal‐resident phagocytes of the central nervous system
(CNS) that actively support, defend and modulate the neural environment. Dysfunctional …

There are still no effective treatments to prevent, halt, or reverse Alzheimer's disease, but
research advances over the past three decades could change this gloomy picture. Genetic …

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the
elderly individuals. Clinically, patients initially present with short-term memory loss …

The APOE ε4 allele is a risk factor for late-life pathological changes that is also associated
with anatomical and functional brain changes in middle-aged and elderly healthy subjects …