The prevailing motor neuron-centric view of amyotrophic lateral sclerosis (ALS)
pathogenesis could be an important factor in the failure to identify disease-modifying therapy …

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease among
adults. With diagnosis reached relatively late into the disease process, extensive motor cell …

Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system.
Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is …

Amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease involving complex
genetic and environmental factors, is associated with neuroinflammation. Preclinical and …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the loss of upper and lower motor neurons. Presently, three FDA-approved drugs are …

Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease with poorly
understood clinical heterogeneity, underscored by significant differences in patient age at …

The routine clinical integration of individualized objective markers of disease activity in those
diagnosed with the neurodegenerative disorder amyotrophic lateral sclerosis is a key …

Abstract Chitinase‐3‐like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its
ability to regulate multiple biological processes, such as the inflammatory response and …

Objective Amyotrophic lateral sclerosis (ALS) is a complex disease with numerous
pathological mechanisms resulting in a heterogeneous patient population. Using …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
loss of upper and lower motor neurons, resulting in progressive weakness of all voluntary …