During Parkinson's disease (PD), both the central nervous system (CNS) and peripheral
nervous system (PNS) are affected. In parallel, innate immune cells respond early to …

Abstract Alpha-synuclein (α-syn) has been suggested to have many functions including,
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …

The ability to use blood to predict the outcomes of Parkinson's disease, including disease
progression and cognitive and motor complications, would be of significant clinical value …

Parkinson's disease (PD) is a serious neurodegenerative disorder marked by significant
clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD …

Summary The Foundational Data Initiative for Parkinson Disease (FOUNDIN-PD) is an
international collaboration producing fundamental resources for Parkinson disease (PD) …

Background Genetic mutations in beta-glucocerebrosidase (GBA) represent the major
genetic risk factor for Parkinson's disease (PD). GBA participates in both the endo-lysosomal …

Multiple lines of clinical and pre-clinical research support a pathogenic role for
neuroinflammation and peripheral immune system dysfunction in Parkinson's disease. In …

Transfer RNA fragments (tRFs) have recently been shown to be an important family of small
regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood …

Increasing evidence suggests a potential role for infectious pathogens in the etiology of
synucleinopathies, a group of age-related neurodegenerative disorders including …

Abstract The LRRK2 G2019S pathogenic mutation causes LRRK2-associated Parkinson's
disease (L2PD) with incomplete penetrance. LRRK2 non-manifesting carriers (L2NMC) are …