Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals

F Abbaszadeh, S Fakhri, H Khan - Pharmacological Research, 2020 - Elsevier
Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …

Pathophysiology of cervical myelopathy

DC Baptiste, MG Fehlings - The Spine Journal, 2006 - Elsevier
BACKGROUND CONTENT: Cervical myelopathy is a group of closely related disorders
usually caused by spondylosis or by ossification of the posterior longitudinal ligament and is …

[HTML][HTML] Degenerative cervical myelopathy: pathophysiology and current treatment strategies

SH Choi, CN Kang - Asian spine journal, 2020 - ncbi.nlm.nih.gov
Chronic compression or ischemia of the spinal cord in the cervical spine causes a clinical
syndrome known as cervical myelopathy. Recently, a new term “degenerative cervical …

N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K/AKT pathway

J Kang, Y Wang, X Guo, X He, W Liu, H Chen, Z Wang… - Cell Cycle, 2022 - Taylor & Francis
ABSTRACT N-acetylserotonin (NAS) exerts neuroprotective, antioxidant, and anti-apoptotic
effects. Oxidative stress and apoptosis are the primary causes of spinal cord injury (SCI) …

The role of DTI in early detection of cervical spondylotic myelopathy: a preliminary study with 3-T MRI

B Kara, A Celik, S Karadereler, L Ulusoy… - Neuroradiology, 2011 - Springer
Introduction The radiological diagnosis of cervical spondylotic myelopathy (CSM) has to be
made as soon as possible, since surgery performed in earlier stages during the course of …

[HTML][HTML] Update of the natural history, pathophysiology, and treatment strategies of degenerative cervical myelopathy: a narrative review

MW Kim, CN Kang, SH Choi - Asian Spine Journal, 2023 - ncbi.nlm.nih.gov
Cervical myelopathy is a clinical syndrome resulting in symptoms of neurologic deficits due
to prolonged spinal cord compression or ischemia in the cervical spine. Spinal cord …

The adult spinal cord injury without radiographic abnormalities syndrome: magnetic resonance imaging and clinical findings in adults with spinal cord injuries having …

GB Kasimatis, E Panagiotopoulos… - Journal of Trauma …, 2008 - journals.lww.com
Background: Spinal cord injury without radiographic abnormalities (SCIWORA) is thought to
represent mostly a pediatric entity and its incidence in adults is rather underreported. Some …

Advances in MR imaging for cervical spondylotic myelopathy

BM Ellingson, N Salamon, LT Holly - European Spine Journal, 2015 - Springer
Purpose To outline the pathogenesis of cervical spondylotic myelopathy (CSM), the
correlative abnormalities observed on standard magnetic resonance imaging (MRI), the …

Cortical reorganization in patients with cervical spondylotic myelopathy

LT Holly, Y Dong, R Albistegui-DuBois… - … of Neurosurgery: Spine, 2007 - thejns.org
Object Recent investigations have demonstrated that the cerebral cortex can reorganize as
a result of spinal cord injury and may play a role in preserving neurological function …

The extent of myelin pathology differs following contusion and transection spinal cord injury

MM Siegenthaler, MK Tu, HS Keirstead - Journal of neurotrauma, 2007 - liebertpub.com
Demyelination is a prominent feature of spinal cord injury (SCI) and is followed by
incomplete remyelination, which may contribute to physiological impairment. Demyelination …