Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the
necrosis of tumors, but it has been recently identified to have additional important functions …

ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …

Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant
roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its …

The severe‐acute‐respiratory‐syndrome‐coronavirus‐2 (SARS‐CoV‐2) is the causative
agent of COVID‐19, but host cell factors contributing to COVID‐19 pathogenesis remain only …

Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

Tumor necrosis factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor
1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 …

Tumor necrosis factor alpha (TNF; TNFα) is a critical regulator of immune responses in
healthy organisms and in disease. TNF is involved in the development and proper …

Abstract Tumor Necrosis Factor (TNF), initially known for its tumor cytotoxicity, is a potent
mediator of inflammation, as well as many normal physiological functions in homeostasis …

Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Tumor necrosis factor (TNF) is the prototypic pro-inflammatory cytokine. It is central to host
defense and inflammatory responses but under certain circumstances also triggers cell …