Background: Organisms are constantly exposed to physiological and environmental
stresses and therefore require an efficient surveillance of genome and proteome quality in …

Several isoforms of apolipoprotein J/clusterin (CLU) are encoded from a single gene located
on chromosome 8 in humans. These isoforms are ubiquitously expressed in the tissues, and …

The introduction of pre-storage leukoreduction in the preparation of standard RBCs intended
for transfusion provided significant improvement in the quality of labile products and their …

BACKGROUND Blood transfusion is a lifesaving intervention for millions of recipients
worldwide every year. Storing blood makes this possible but also promotes a series of …

Although the molecular pathways leading to the progressive deterioration of stored red
blood cells (RBC storage lesion) and the clinical relevance of storage‐induced changes …

BACKGROUND Cigarette smoking is a frequent habit across blood donors (approx. 13% of
the donor population), that could compound biologic factors and exacerbate oxidant stress …

The cardiometabolic syndrome involves a clustering of metabolic and cardiovascular factors
which increase the risk of patients developing both Type 2 Diabetes Mellitus and cardio …

The ability to detect and target β cells in vivo can substantially refine how diabetes is studied
and treated. However, the lack of specific probes still hampers a precise characterization of …

Red blood cells (RBCs) have been historically regarded as a critical model to investigate
cellular and oxidant stress biology. First of all, they are constantly exposed to oxidant stress …

BACKGROUND Oxidative stress orchestrates a significant part of the red blood cell (RBC)
storage lesion. Considering the tremendous interdonor variability observed in the …