Abstract Background Membrane proteins (MPs) play diverse and important functions in
living organisms. They constitute 20% to 30% of the known bacterial, archaean and …

The determination of membrane protein (MP) structures has always trailed that of soluble
proteins due to difficulties in their overexpression, reconstitution into membrane mimetics …

Background Membrane transport proteins (transporters) move hydrophilic substrates across
hydrophobic membranes and play vital roles in most cellular functions. Transporters …

We discuss recent progresses in computational studies of membrane proteins based on
physical models with parameters derived from bioinformatics analysis. We describe …

Motivation: Helix–helix interactions play a critical role in the structure assembly, stability and
function of membrane proteins. On the molecular level, the interactions are mediated by one …

Transmembrane proteins (TMPs) are critical components of cellular life. However, due to
experimental challenges, the number of experimentally resolved TMP structures is severely …

Background Sequence homology considerations widely used to transfer functional
annotation to uncharacterized protein sequences require special precautions in the case of …

GPCR oligomerization has emerged as a hot topic in the GPCR field in the last years.
Receptors that are part of these oligomers can influence each other's function, although it is …

Background: Communication within a protein complex is mediated by physical interactions
made among the protomers. Evidence for both the allosteric regulation present among the …

The α-helical transmembrane proteins constitute 25% of the entire human proteome space
and are difficult targets in high-resolution wet-lab structural studies, calling for accurate …