Host genetic factors determining COVID-19 susceptibility and severity

TP Velavan, SR Pallerla, J Rüter, Y Augustin… - …, 2021 - thelancet.com
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2
(SARS-CoV-2) poses an unprecedented challenge to humanity. SARS-CoV-2 infections …

Genetic polymorphisms of ACE1, ACE2, and TMPRSS2 associated with COVID‐19 severity: A systematic review with meta‐analysis

W Saengsiwaritt, J Jittikoon… - Reviews in medical …, 2022 - Wiley Online Library
Abstract Novel coronavirus disease 2019 (COVID‐19) poses a global threat, due to its
fluctuating frequency and lethality. Published data revealed associations of COVID‐19 …

Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity

K Gupta, G Kaur, T Pathak, I Banerjee - Gene, 2022 - Elsevier
The COVID-19 pandemic has spawned global health crisis of unprecedented magnitude,
claiming millions of lives and pushing healthcare systems in many countries to the brink …

Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis

C Dieter, LA Brondani, CB Leitão, F Gerchman… - PLoS …, 2022 - journals.plos.org
Although advanced age and presence of comorbidities significantly impact the variation
observed in the clinical symptoms of COVID-19, it has been suggested that genetic variants …

Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19

C Dieter, L de Almeida Brondani, NE Lemos… - Genes, 2022 - mdpi.com
Although advanced age, male sex, and some comorbidities impact the clinical course of
COVID-19, these factors only partially explain the inter-individual variability in disease …

The complexity of SARS-CoV-2 infection and the COVID-19 pandemic

MK da Silva Torres, CDA Bichara… - Frontiers in …, 2022 - frontiersin.org
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) led to the death of millions of people worldwide and thousands more infected individuals …

Genetic polymorphisms of ACE1, ACE2, IFTM3, TMPRSS2 and TNFα genes associated with susceptibility and severity of SARS-CoV-2 infection: A systematic review …

V Pecoraro, M Cuccorese, T Trenti - Clinical and Experimental Medicine, 2023 - Springer
Background Some human polymorphisms of ACE1, ACE2, IFITM3, TMPRSS2 and TNFα
genes may have an effect on the susceptibility to SARS-CoV-2 infection and increase the …

Angiotensin–Converting Enzyme (ACE) 1 Gene Polymorphism and Phenotypic Expression of COVID-19 Symptoms

N Yamamoto, N Nishida, R Yamamoto, T Gojobori… - Genes, 2021 - mdpi.com
The renin–angiotensin–aldosterone system (RAAS) appears to play an important role in
SARS-CoV-2 infection. Polymorphisms within the genes that control this enzymatic system …

[HTML][HTML] The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity: A systematic review and meta-analysis

Z Dobrijevic, D Robajac, N Gligorijevic, M Šunderic… - EXCLI …, 2022 - ncbi.nlm.nih.gov
Genes involved in the regulation of viral recognition and its entry into a host cell have been
identified as candidates for genetic association studies on COVID-19 severity. Published …

Severity of coronavirus disease 19: Profile of inflammatory markers and ACE (rs4646994) and ACE2 (rs2285666) gene polymorphisms in Iraqi patients

ZS Mahmood, HY Fadhil, TAA Hussein, AH Ad'hiah - Meta gene, 2022 - Elsevier
Susceptibility to coronavirus disease 2019 (COVID-19) and disease severity has recently
been associated with inflammatory markers and genetic polymorphisms of ACE (angiotensin …